How Does Drug Use Change The Brain

Chronic cocaine exposure affects many other areas of the brain too. For example, animal research indicates that cocaine diminishes functioning in the orbitofrontal cortex (OFC), which appears to underlie the poor decision-making, inability to adapt to negative consequences of drug use, and lack of self-insight shown by people addicted to cocaine.12 A study using optogenetic technology, which uses light to activate specific, genetically-modified neurons, found that stimulating the OFC restores adaptive learning in animals. This intriguing result suggests that strengthening OFC activity may be a good therapeutic approach to improve insight and awareness of the consequences of drug use among people addicted to cocaine.13

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In 1972 David Rash had a problem. He could not find the Exhaust Pipe he needed for his race bike. He knew that the proper exhaust for his engine configuration would give him an edge over his competition. However, no such pipe was available. So he did the only thing he could do.

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